RO1138452

CAS: 221529-58-4

Ref. TM-T4436

Información del producto

• Nombre: RO1138452
• Sinónimos: CAY10441, Cay 10441, Ro 1138452

Descripción

RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1].

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 309.41
• Fórmula: C₁₉H₂₃N₃O
• Pureza: 99.34%
• Color/Forma: Solid