SB297006

CAS: 58816-69-6

Ref. TM-T4674

Información del producto

• Nombre: SB297006
• Sinónimos: SB 297006
• CAS: 58816-69-6

Descripción

SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 342.35
• Fórmula: C₁₈H₁₈N₂O₅
• Pureza: 99.65%
• Color/Forma: Solid