NSC697923

CAS: 343351-67-7

Ref. TM-T6611

Información del producto

• Nombre: NSC697923
• Sinónimos: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran
• CAS: 343351-67-7

Descripción

NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-κB signaling, further contributing to its antitumor activity.

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 267.26
• Fórmula: C₁₁H₉NO₅S
• Pureza: 99.69%
• Color/Forma: Solid