BNIP3 Protein, Mouse, Recombinant (Cell-Free, His)

Ref. TM-TMPH-02536

Información del producto

• Nombre: BNIP3 Protein, Mouse, Recombinant (Cell-Free, His)
• Sinónimos: Bnip3, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, Nip3

Descripción

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 23.8 kDa (predicted)
• Color/Forma: Solid