PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated

Ref. TM-TMPJ-00369

Información del producto

• Nombre: PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated
• Sinónimos: Subtilisin/Kexin-Like Protease PC9, PCSK9, NARC1, Proprotein Convertase Subtilisin/Kexin Type 9, PC9, Neural Apoptosis-Regulated Convertase 1, Proprotein Convertase 9, NARC-1

Descripción

Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 18&58-70&90-150 KDa, reducing conditions
• Color/Forma: Solid