NTAQ1 Protein, Human, Recombinant (GST)

Ref. TM-TMPJ-00489

Información del producto

• Nombre: NTAQ1 Protein, Human, Recombinant (GST)
• Sinónimos: Nt(Q)-amidase, C8orf32, NTAQ1, Protein NH2-terminal glutamine deamidase, Protein N-terminal glutamine amidohydrolase, N-terminal Gln amidase, WDYHV1

Descripción

Human protein N-terminal glutamine amidohydrolase (WDYHV1) is an enzyme that in humans is encoded by the WDYHV1 gene, belongs to the NTAQ1 family.WDYHV1 mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, which is an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. However,it does not act on substrates with internal or C-terminal glutamine andnon-glutamine residues in any position. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.

• Marca: Targetmol

Propiedades químicas

• Peso molecular: 45-50 KDa (reducing condition)
• Color/Forma: Solid