(r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4 -yl]propionic Acid Sesquihydrate

CAS: 209977-56-0

Ref. TR-A603150

Información del producto

• Nombre: (r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4 -yl]propionic Acid Sesquihydrate
• Sinónimos: 2-amino-3-[3-(carboxymethoxy)-5-methyl-1,2-oxazol-4-yl]propanoic acid;trihydrate, 4-Isoxazolepropanoic acid, α-amino-3-(carboxymethoxy)-5-methyl-, hydrate (2:3)

Descripción

Stability Store in freezer at -20°C
Applications A selective inhibitor of [3H]-AMPA binding in rat brain membranes. AMOA shows little affinity for [3H]-kainate binding sites or other sites on the NMDA receptor-channel complex, as represented by binding of [3H]-CPP, [3H]-gly or [3H]-MK-801. AMOA also selectively antagonizes AMPA-induced responses in rat cortical wedge preparations relative to kainate-, quisqualate- and NMDA-induced responses.
References Frandsden, A., et al.: J. Neurochem., 55, 1821 (1990), Krogsgaard-Larsen, P., et al.: J. Med. Chem., 34, 123 (1991), Berg, M., et al.: Acta Neuropathalogica, 81, 255 (1991)

• Marca: TRC

Propiedades químicas

• Peso molecular: 542.45
• Fórmula: C₉H₁₂N₂O₆H₂O
• Color/Forma: Neat
• InChI: InChI=1S/2C9H12N2O6.3H2O/c2*1-4-5(2-6(10)9(14)15)8(11-17-4)16-3-7(12)13;;;/h2*6H,2-3,10H2,1H3,(H,12,13)(H,14,15);3*1H2
• Clave InChI: InChIKey=USUJSFZGKHCJBJ-UHFFFAOYSA-N
• SMILES: Cc1onc(OCC(=O)O)c1CC(N)C(=O)O.Cc1onc(OCC(=O)O)c1CC(N)C(=O)O.O.O.O