4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide

CAS: 757251-39-1

Ref. TR-A609725

Información del producto

• Nombre: 4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
• Sinónimos: 2-Pyridinecarboxamide, 4-(4-amino-3-fluorophenoxy)-N-methyl-, 4-(4-Amino-3-fluorophenoxy)-N-methyl-2-pyridinecarboxamide, 4-(4-Amino-3-fluorophenoxy)pyridine-2-carboxylic acid methylamide
• Marca: TRC
• Descripción: Applications 4-(4-Amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide is a compound used as a reagent to synthesize Regorafenib (R143000), a multikinase inhibitor that is used to treat patients with advanced colorectal cancer.References Mross, K., et al.: Clin. Cancer Res., 18, 2658 (2012); Stiehl, J., et al. Process for Preparation of Regorafenib. PCT Int. Appl. 2011128261. Oct 20, 2011; Van Cutsem, E., et al.: J. Clin. Oncol., 30, 3502 (2012)

Propiedades químicas

• Peso molecular: 261.25
• Fórmula: C₁₃H₁₂FN₃O₂
• Color/Forma: Dark Orange To Red Brown
• InChI: InChI=1S/C13H12FN3O2/c1-16-13(18)12-7-9(4-5-17-12)19-8-2-3-11(15)10(14)6-8/h2-7H,15H2,1H3,(H,16,18)
• Clave InChI: InChIKey=ZQHJPIPGBODVTG-UHFFFAOYSA-N
• SMILES: CNC(=O)c1cc(Oc2ccc(N)c(F)c2)ccn1