9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d3 Maleate

CAS: 1219806-48-0

Ref. TR-A629902

Información del producto

• Nombre: 9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d3 Maleate
• Sinónimos: 9-Amino-1,2,2-trideuterio-3,4-dihydroacridin-1-ol but-2-enedioic acid, 9-Amino-1,2,3,4-tetrahydroacridin-1-ol-1,2,2-D3 maleate, 9-Amino-1,2,3,4-tetrahydro-1-acridinol-1,2,2-d3 maleate, (±)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol-1,2,2-d3 maleate, 1-Hydroxytacrine-1,2,2-d3 maleate, Hydroxytacrine-d3 maleate, Velnacrine-d3 maleate, Velnacrine-1,2,2-D3 maleate
• Marca: TRC

Descripción

Applications A potential Alzheimer's Disease therapeutic of low toxicity. Exhibits biochemical and pharmacological profile similar to THA except that it is far less toxic and without measurable liver toxicity in humans.
References Alon, R., et al.: J. Cell Biol., 128, 1243 (1995), Min, W., et al.: J .Immunol., 159, 3508 (1997), Lum, A., et al.: J. Biol. Chem., 277, 20660 (2002), Carvalho, F., et al.: J. Appl. Toxicol., 24, 419 (2004),

Propiedades químicas

• Peso molecular: 333.354
• Fórmula: C₁₃D₃H₁₁N₂O·C₄H₄O₄
• Color/Forma: Neat
• InChI: InChI=1S/C13H14N2O.C4H4O4/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13;5-3(6)1-2-4(7)8/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-/i7D2,11D
• Clave InChI: InChIKey=NEEKVKZFYBQFGT-DPIYXFFGSA-N
• SMILES: O=C(O)/C=C\C(=O)O.[2H]C1([2H])CCc2[nH]c3ccccc3c(=N)c2C1([2H])O