Apigenin

CAS: 520-36-5

Ref. TR-A726500

Información del producto

• Nombre: Apigenin
• Sinónimos: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, 4',5,7-Trihydroxyflavone, Pelargidenon 1449, 4′,5,7-Trihydroxyflavone, 5,7,4'-Trihydroxyflavone, 5,7-Dihidroxi-2-(4-Hidroxifenil)-4-Benzopirona, 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-4-Benzopyrone, 5,7-Dihydroxy-2-(4-Hydroxyphenyl)chromen-4-one, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron, 5,7-Dihydroxy-2-p-hydroxyphenyl-4-chromenone, Apegenin, Apigenine, Apigenol, Chamomile, Flavone, 4',5,7-trihydroxy-, Flavone, 4′,5,7-trihydroxy-, Ly 080400, Nsc 83244, St 056301, Uccf 031, Versulin, 75580, 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, C.I. Natural Yellow 1, 75590

Descripción

Applications Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 uM) by inhibiting MAP kinase activity. Also inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation. Apigenin has also been reported to enhance the gap juntion intracellular communication in liver cells.uv(max)ethanol: 269, 340 nm (e= 18,800, 20,900) moderately sol. in hot alcohol
References Chaumontet, C., et al.: Carcinogenesis, 15, 2325 (1994); Sato, F., et al.: Biochem. Biophys. Res. Commun., 204, 578 (1994); Kuo, M.L. et al.: Biochem. Biophys. Res. Commun., 212, 767 (1995);

• Marca: TRC

Propiedades químicas

• Peso molecular: 270.24
• Fórmula: C₁₅H₁₀O₅
• Color/Forma: Yellow To Brown
• InChI: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
• Clave InChI: InChIKey=KZNIFHPLKGYRTM-UHFFFAOYSA-N
• SMILES: O=c1cc(-c2ccc(O)cc2)oc2cc(O)cc(O)c12