Auranofin

CAS: 34031-32-8

Ref. TR-A794750

Información del producto

• Nombre: Auranofin
• Sinónimos: Gold, [1-(thio-?S)-ß-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-, Gold, (1-thio-ß-D-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate (8CI), Gold, (1-thio-ß-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-, [1-(Thio-?S)-ß-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)gold, ß-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, gold complex, Aktil, Crisinor, Crisofin, NSC 321521, Ridaura, Ridauran, SKF 39162, SKF 39162D, [(Tetra-O-acetyl-ß-D-glucopyranosyl)thio](triethylphosphine)gold, (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate, 3,4,5-Triacetoxy-6-(Acetoxymethyl)Tetrahydropyran-2-Thiolate, Auranofina, Auranofine, Gold Salt, Gold(+1) Cation, Gold, (1-thio-β-<span class="text-smallcaps">D</span>-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate, Gold, (1-thio-β-<span class="text-smallcaps">D</span>-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-, Gold, (1-thio-β-D-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate, Gold, (1-thio-β-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-, Gold, [1-(thio-κS)-β-<span class="text-smallcaps">D</span>-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-, Gold, [1-(thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-, Nsc 321521, Phosphine, Triethyl-, Gold(1+) Salt (1:1), Skf 39162, Skf 39162D, Triethylphosphonium, [(Tetra-O-acetyl-β-<span class="text-smallcaps">D</span>-glucopyranosyl)thio](triethylphosphine)gold, [(Tetra-O-acetyl-β-D-glucopyranosyl)thio](triethylphosphine)gold, [1-(Thio-κS)-β-<span class="text-smallcaps">D</span>-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)gold, β-<span class="text-smallcaps">D</span>-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, gold complex

Descripción

Applications Auranofin is a new oral gold-based antiarthritis drug. Auranofin inhibits various leukocyte activation pathways at multiple sites. Auranofin inhibits the release of inflammatory mediators from human macrophages, basophils, and pulmonary mast cells. Auranofin is an efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions related to its inhibition of mitochondrial thioredoxin reductase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kizu, R., et al.: Chem. Pharm. Bull., 41, 1261 (1993), Itokazu, M., et al.: Clin. Ther., 17, 60 (1995), Kean, W.F., et al.: Br. J. Rheumatol., 36, 560 (1997),

• Marca: TRC

Propiedades químicas

• Peso molecular: 678.48
• Fórmula: C₂₀H₃₄AuO₉PS
• Color/Forma: Neat
• InChI: InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1/t10-,11-,12+,13-,14+;;/m1../s1
• SMILES: CC(=O)OC[C@H]1O[C@@H]([S-])[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O.CCP(CC)CC.[Au+]