Información del producto
- (R)-3a-(Benzoyloxy)-1,2,3,3a-tetrahydro-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Applications (R)-(+)-Blebbistatin O-Benzoate is a derivative of Blebbistatin (B592495). (R)-(+)-Blebbistatin is a 1-phenyl-2-pyrrolidinone derivative and a selective inhibitor of non-muscle myosin II (1, 2, 3). It blocks cell blebbing rapidly and reversibly and also disrupts directed cell migration and cytokinesis in vertebrate cell. (R)-(+)-Blebbistatin can also inhibit contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (R)-(+)-Blebbistatin is suitable as a negative control for (S)-(-)-Blebblastatin.
References (1) Straight, A.F., et al.: Science (2003) 299: 1743-7(2) Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun (2004) 313: 992-7 (3) Kovacs, M., et al.: J. Biol. Chem. (2004) 279: 35557-63