Boc-3-hydroxy-1-adamantyl-glycine

CAS: 1334321-39-9

Ref. TR-B656425

Información del producto

• Nombre: Boc-3-hydroxy-1-adamantyl-glycine
• Sinónimos: (2R)-2-((tert-Butoxycarbonyl)amino)-2-(3-hydroxyadamantan-1-yl)acetic Acid, (alphaR)-alpha-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hydroxy-tricyclo[3.3.1.13,7]decane-1-acetic Acid

Descripción

Applications Boc-3-hydroxy-1-adamantyl-glycine is an impurity of Saxagliptin (S143500), which is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.
References Feng, J., et al.: J. Med. Chem., 50, 2297 (2007), Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008), Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2008),

• Marca: TRC

Propiedades químicas

• Peso molecular: 325.4
• Fórmula: C₁₇H₂₇NO₅
• Color/Forma: White to Off-White Solid
• InChI: InChI=1S/C17H27NO5/c1-15(2,3)23-14(21)18-12(13(19)20)16-5-10-4-11(6-16)8-17(22,7-10)9-16/h10-12,22H,4-9H2,1-3H3,(H,18,21)(H,19,20)/t10-,11+,12-,16+,17-/m0/s1
• Clave InChI: InChIKey=UKCKDSNFBFHSHC-ABXZDOEHSA-N
• SMILES: CC(C)(C)OC(=O)N[C@@H](C(=O)O)[C@@]12C[C@@H]3C[C@@H](C[C@@](O)(C3)C1)C2