Cabozantinib L-Malate Salt

CAS: 1140909-48-3

Ref. TR-C051500

Información del producto

• Nombre: Cabozantinib L-Malate Salt
• Sinónimos: Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1), Cabozantinib S-malate, Cabozantinib s-malate, Cometriq, XL 184, Cabozantinib (S)-malate
• Marca: TRC
• Descripción: Applications Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.References Camp, R., et al.: Cancer, 86, 2259 (1999), Morello, S., et al.: J. Cell Physiol., 189, 285 (2001), Zhang, Y., et al.: Oncogene, 21, 217 (2002), Wells, S., et al.: J. Clin. Oncol., 28, 767 (2010),

Propiedades químicas

• Peso molecular: 635.59
• Fórmula: C₂₈H₂₄FN₃O₅·C₄H₆O₅
• Color/Forma: Neat
• InChI: InChI=1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1
• Clave InChI: InChIKey=HFCFMRYTXDINDK-WNQIDUERSA-N
• SMILES: COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC.O=C(O)C[C@H](O)C(=O)O