(3S)-4-Chloro-3-hydroxybutyronitrile

CAS: 127913-44-4

Ref. TR-C366605

Información del producto

• Nombre: (3S)-4-Chloro-3-hydroxybutyronitrile
• Sinónimos: (3S)-4-Chloro-3-hydroxybutanenitrile, (S)-4-Chloro-3-hydroxybutanenitrile, (S)-(-)-4-Chloro-3-hydroxybutyronitrile, (S)-4-Chloro-3-hydroxybutyronitrile, S-(-)-4-chloro-3-hydorxy butyronitrile, (3S)-4-chloro-3-hydorxybutyronitrile, (3R)-4-chloro-3-hydroxybutanenitrile, (3S)-4-chloro-3-hydroxybutanenitrile

Descripción

Applications (3S)-4-Chloro-3-hydroxybutyronitrile is used in various organic precursor syntheses. It is used in the synthesis of hydroxypyrrolidinones to by used as carbapenem precursors. Also used in the preparation of atorvastatin (A791750) precursors. Impurity in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
References Kanno, O. et al.: Hetero., 53, 173 (2000); Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006); Jiang, C. et al.: Lett. Org. Chem., 9, 520 (2012);

• Marca: TRC

Propiedades químicas

• Peso molecular: 119.55
• Fórmula: C₄H₆ClNO
• Color/Forma: Neat
• InChI: InChI=1S/C4H9ClO/c1-2-4(6)3-5/h4,6H,2-3H2,1H3/t4-/m0/s1
• Clave InChI: InChIKey=VNBFUGOVQMFIRN-BYPYZUCNSA-N
• SMILES: N#CC[C@H](O)CCl