5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid

CAS: 162758-35-2

Ref. TR-C377830

Información del producto

• Nombre: 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid
• Sinónimos: 1-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic Acid, 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic Acid
• Marca: TRC

Descripción

Applications 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic Acid is used in the preparation of biarylpyrazole based derivatives as cannabinoid CB1 receptor antagonists. It is metabolite M9 of Rimonabant (R517800), an antiobesity agent.
References Kang, S.Y. et al.: Bioorg. Med. Chem. Lett., 18, 2385 (2008); Fulp, A. et al.: Bioorg. Med. Chem. Lett., 21, 5711 (2011); Bergstrom, M.A. et al.: Drug Metab. and Dispos., 39, 1823 (2011);

Propiedades químicas

• Peso molecular: 381.64
• Fórmula: C₁₇H₁₁Cl₃N₂O₂
• Color/Forma: Neat
• InChI: InChI=1S/C17H11Cl3N2O2/c1-9-15(17(23)24)21-22(14-7-6-12(19)8-13(14)20)16(9)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,23,24)
• Clave InChI: InChIKey=CYAYCOCJAVHQSD-UHFFFAOYSA-N
• SMILES: Cc1c(C(=O)O)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1