(R)-2-[[4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide

CAS: 1146699-66-2

Ref. TR-C379830

Información del producto

• Nombre: (R)-2-[[4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
• Sinónimos: (2R)-2-[N-[(4-Chlorophenyl)sulfonyl]-N-[[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide, Avagacestat, BMS 708163, BMS 708163-01
• Marca: TRC
• Descripción: Applications Avagacestat acts as a γ-secretase inhibitor allowing for treatment of ALzheimer’s disease. On addition it has seen uses targeting embryonic signaling pathways, which control stem cell and cellular development process in cancer therapy.References Harris, PJ. et al.: Expert. Opin. Ther. Tar., 16, 131 (2012); Gilman, K.W. et al.: ACS Med. Chem. Lett., 1, 120 (2010)

Propiedades químicas

• Peso molecular: 520.88
• Fórmula: C₂₀H₁₇ClF₄N₄O₄S
• Color/Forma: Neat
• InChI: InChI=1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,26,30)/t17-/m1/s1
• Clave InChI: InChIKey=XEAOPVUAMONVLA-QGZVFWFLSA-N
• SMILES: NC(=O)[C@@H](CCC(F)(F)F)N(Cc1ccc(-c2ncon2)cc1F)S(=O)(=O)c1ccc(Cl)cc1