β-Cortolone

CAS: 667-66-3

Ref. TR-C696285

Información del producto

• Nombre: β-Cortolone
• Sinónimos: (3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-11-one, (3alpha,5beta,20R)-3,17,20,21-tetrahydroxypregnan-11-one, (3α,5β,20R)-3,17,20,21-Tetrahydroxypregnan-11-one, 11-Pregnanone, 3α,17,20β,21-tetrahydroxy-, 20β-Cortolone, 20β-Hexahydrocortisone, 3-Alpha,17-Alpha,20-Beta,21-Tetrahydroxy-5-Beta-Pregnan-11-One, 3α,17,20β,21-Tetrahydroxy-5β-pregnan-11-one, 3α,17α,20β,21-Tetrahydroxy-5β-pregnan-11-one, 5β-Pregnan-11-one, 3α,17,20β,21-tetrahydroxy-, 5β-Pregnan-3α,17α,20β,21-tetrol-11-one, 5β-Pregnane-3α,17α,20β,21-tetrol-11-one, NSC 56997, Pregnan-11-one, 3,17,20,21-tetrahydroxy-, (3α,5β,20R)-

Descripción

Applications β-Cortolone is a metabolite of Cortisol (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
References Fukushima, D.K., et. al.: Steroids, 35, 209 (1980); Vigore, L., et al.: Cancer Ther., 6, 699 (2008); Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009); Lemos, D., et al.: J. Endocrinol., 201, 275 (2009); Chen, S., et al.: Am. J. Physiol., 296 (2009)

• Marca: TRC

Propiedades químicas

• Peso molecular: 366.49
• Fórmula: C₂₁H₃₄O₅
• Color/Forma: Off-White
• InChI: InChI=1S/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,17-18,22-23,25-26H,3-11H2,1-2H3/t12-,13-,14+,15+,17-,18-,19+,20+,21+/m1/s1
• Clave InChI: InChIKey=JXCOSKURGJMQSG-AIEJOZITSA-N
• SMILES: C[C@]12CC[C@@H](O)C[C@H]1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@]2(O)[C@H](O)CO