5-Dehydro Tolvaptan-d7

CAS: 1296212-29-7

Ref. TR-D230352

Información del producto

• Nombre: 5-Dehydro Tolvaptan-d7
• Sinónimos: N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide-d7, 1H-1-Benzazepine, Benzamide Deriv.-d7, 7-Chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-Oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-d7

Descripción

Applications 5-Dehydro Tolvaptan-d7 is an intermediate in synthesizing Tolvaptan-d7 (T536652), a labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006)

• Marca: TRC

Propiedades químicas

• Peso molecular: 453.97
• Fórmula: C₂₆H₁₆D₇ClN₂O₃
• Color/Forma: Neat
• InChI: InChI=1S/C26H23ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15H,5,8,13H2,1-2H3,(H,28,31)/i1D3,3D,4D,6D,7D
• Clave InChI: InChIKey=VENGMROMZOKURN-FFQSSJIFSA-N
• SMILES: [2H]c1c([2H])c([2H])c(C([2H])([2H])[2H])c(C(=O)Nc2ccc(C(=O)N3CCCC(=O)c4cc(Cl)ccc43)c(C)c2)c1[2H]