N-Desmethyl Imatinib

CAS: 404844-02-6

Ref. TR-D292045

Información del producto

• Nombre: N-Desmethyl Imatinib
• Sinónimos: N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide, N-Desmethylimatinib, N-[4-Methyl-3-[4-(pyridin-3-yl)pyrimidin-2-ylamino]phenyl]-4-[(piperazin-1-yl)methyl]benzamide, N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)benzamide, Norimatinib, STI 509-00, Imatinib Imp. C (EP), N-Desmethyl gleevec

Descripción

Impurity Imatinib EP Impurity C
Applications N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.
References Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),

• Marca: TRC

Propiedades químicas

• Peso molecular: 479.58
• Fórmula: C₂₈H₂₉N₇O
• Color/Forma: Neat
• InChI: InChI=1S/C28H29N7O/c1-20-4-9-24(17-26(20)34-28-31-12-10-25(33-28)23-3-2-11-30-18-23)32-27(36)22-7-5-21(6-8-22)19-35-15-13-29-14-16-35/h2-12,17-18,29H,13-16,19H2,1H3,(H,32,36)(H,31,33,34)
• Clave InChI: InChIKey=BQQYXPHRXIZMDM-UHFFFAOYSA-N
• SMILES: Cc1ccc(NC(=O)c2ccc(CN3CCNCC3)cc2)cc1Nc1nccc(-c2cccnc2)n1