N-Des-4-morpholineacetic Acid N-Boc-Carfilzomib

CAS: 868540-22-1

Ref. TR-D292970

Información del producto

• Nombre: N-Des-4-morpholineacetic Acid N-Boc-Carfilzomib
• Sinónimos: tert-butyl N-[(2R)-1-[[(2S)-4-methyl-1-[[(2R)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxo-4-phenylbutan-2-yl]carbamate, (αS)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide, L-Phenylalaninamide, (αS)-α-[[(1,1-dimethylethoxy)carbonyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-, L-Phenylalaninamide, (αS)-α-[[(1,1-dimethylethoxy)carbonyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-, (2R)-2-[(2S)-2-[[N-[(S)-2-(tert-Butoxycarbonylamino)-4-phenylbutanoyl]-L-leucyl-L-phenylalanyl]amino]-4-methylpentanoyl]-2-methyloxirane

Descripción

Applications N-Des-4-morpholineacetic Acid N-Boc-Carfilzomib is an impurity of Carfilzomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);

• Marca: TRC

Propiedades químicas

• Peso molecular: 692.885
• Fórmula: C₃₉H₅₆N₄O₇
• Color/Forma: Neat
• InChI: InChI=1S/C39H56N4O7/c1-25(2)21-30(33(44)39(8)24-49-39)40-36(47)32(23-28-17-13-10-14-18-28)42-35(46)31(22-26(3)4)41-34(45)29(43-37(48)50-38(5,6)7)20-19-27-15-11-9-12-16-27/h9-18,25-26,29-32H,19-24H2,1-8H3,(H,40,47)(H,41,45)(H,42,46)(H,43,48)/t29-,30+,31+,32-,39-/m1/s1
• Clave InChI: InChIKey=ZHBDLOMPGLZDJI-QMHUILTPSA-N
• SMILES: CC(C)C[C@H](NC(=O)[C@@H](CCc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1