Desmethyl 5-Methoxycarbonyl Nintedanib (Nintedanib Impurity B)

Ref. TR-D293093

Información del producto

• Nombre: Desmethyl 5-Methoxycarbonyl Nintedanib (Nintedanib Impurity B)
• Marca: TRC
• Descripción: Applications Desmethyl 5-Methoxycarbonyl Nintedanib is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Propiedades químicas

• Peso molecular: 525.6
• Fórmula: C₃₀H₃₁N₅O₄
• Color/Forma: Neat
• InChI: InChI=1S/C30H31N5O4/c1-34-14-16-35(17-15-34)19-26(36)31-22-9-11-23(12-10-22)32-28(20-6-4-3-5-7-20)27-24-18-21(30(38)39-2)8-13-25(24)33-29(27)37/h3-13,18,32H,14-17,19H2,1-2H3,(H,31,36)(H,33,37)/b28-27-
• Clave InChI: InChIKey=FZOUGBXRTSHZCE-DQSJHHFOSA-N
• SMILES: COC(=O)c1ccc2c(c1)/C(=C(/Nc1ccc(NC(=O)CN3CCN(C)CC3)cc1)c1ccccc1)C(=O)N2