Des(sulfonylethyl)amino Hydroxy Lapatinib

CAS: 320337-48-2

Ref. TR-D297423

Información del producto

• Nombre: Des(sulfonylethyl)amino Hydroxy Lapatinib
• Sinónimos: 5-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-furanmethanol
• Marca: TRC
• Descripción: Applications Des(sulfonylethyl)amino Hydroxy Lapatinib is a compound related to drug Lapatinib (L175808), which is a selective inhibitor of epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases. Lapatinib is used to treat breast cancer, especially metastatic breast cancer that has progressed after trastuzumab treatment and other chemotherapy.References Konecny, G., et al.: Cancer Res., 66, 1630 (2006); Geyer, C., et al.: N. Engl. J. Med., 355, 2733 (2006)

Propiedades químicas

• Peso molecular: 475.9
• Fórmula: C₂₆H₁₉ClFN₃O₃
• Color/Forma: Neat
• InChI: InChI=1S/C26H19ClFN3O3/c27-22-12-19(5-8-25(22)33-14-16-2-1-3-18(28)10-16)31-26-21-11-17(4-7-23(21)29-15-30-26)24-9-6-20(13-32)34-24/h1-12,15,32H,13-14H2,(H,29,30,31)
• Clave InChI: InChIKey=KWZZYAKRBYRQTG-UHFFFAOYSA-N
• SMILES: OCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1