4-[(3,5-Dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile

CAS: 1391063-17-4

Ref. TR-D435380

Información del producto

• Nombre: 4-[(3,5-Dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
• Sinónimos: Des(2,4-dichloro-5-methoxyphenyl) 3,5-Dichloro-4-methoxyphenyl Bosutinib
• CAS: 1391063-17-4

Descripción

Applications Kinase inhibitors, such as bosutinib, are useful cancer drugs but their target specificity is not fully understood. 4-[(3,5-Dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile has been employed as a clinical kinase inhibitor bosutinib to elucidate the recognition mechanism between the ATP-binding site and the compound.
References Levinson, N. M. and Boxer, S. G., Nat Chem. Biol 10, 127 (2014); Yen, T. and Beeharry, N., PCT Int. Appl. WO 2013187967 A1 20131219 (2013);

• Marca: TRC

Propiedades químicas

• Peso molecular: 530.45
• Fórmula: C₂₆H₂₉Cl₂N₅O₃
• Color/Forma: White to Light Brown Solid
• SMILES: COc1cc2c(Nc3cc(Cl)c(OC)c(Cl)c3)c(C#N)cnc2cc1OCCCN1CCN(C)CC1