Dihydro Folic Acid

CAS: 4033-27-6

Ref. TR-D449700

Información del producto

• Nombre: Dihydro Folic Acid
• Sinónimos: L-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, Glutamic acid, N-[p-[[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L- (6CI,7CI,8CI), L-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- (9CI), 7,8-Dihydro-L-folic acid, 7,8-Dihydrofolic acid, Dihydrofolic acid, NSC 165989, (2S)-2-[4-[[(2-Amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino]benzamido]pentanedioic acid, (2S)-2-[[4-[[(2-Amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid, 7,8-Dihydro-<span class="text-smallcaps">L</span>-folic acid, <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-, Dihydrofolate, Glutamic acid, N-[p-[[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-, L-Glutamic acid, N-(4-(((2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)- (9CI), N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid, N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid, N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid, Nsc 165989
• CAS: 4033-27-6

Descripción

Stability Hygroscoipic, Light and Air Sensitive
Applications Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).
References Andres, J., et al.: Bioorg. Chem., 24, 10 (1996), Benkovic, S., et al.: Science, 301, 1196 (2003), ,,,,Williams, D; J Mol Biol 2003, 329, 389,,,Krahn, J., et al.: Biochemistry, 46, 14878 (2007),

• Marca: TRC

Propiedades químicas

• Peso molecular: 443.41
• Fórmula: C₁₉H₂₁N₇O₆
• Color/Forma: Beige
• InChI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1
• Clave InChI: InChIKey=OZRNSSUDZOLUSN-LBPRGKRZSA-N
• SMILES: Nc1nc(=O)c2c([nH]1)NCC(CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)=N2