2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one

CAS: 277299-70-4

Ref. TR-D476930

Información del producto

• Nombre: 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one
• Sinónimos: 2-(3,4-dimethylphenyl)-5-methyl-1H-pyrazol-3-one, 3H-Pyrazol-3-one, 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-, 1-(3,4-dimethylphenyl)-3-methyl-1H-pyrazol-5-ol, Stock6S-35344, Zinc09530926, 2-(3,4-dimethylphenyl)-5-methyl-1H-pyrazol-3(2H)-one, EltroMbopag II
• CAS: 277299-70-4

Descripción

Applications 2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one, is an impurity of Eltrombopag (E508000), which is agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.
References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),

• Marca: TRC

Propiedades químicas

• Peso molecular: 202.25
• Fórmula: C₁₂H₁₄N₂O
• Color/Forma: Neat
• InChI: InChI=1S/C12H14N2O/c1-8-4-5-11(6-9(8)2)14-12(15)7-10(3)13-14/h4-7,13H,1-3H3
• Clave InChI: InChIKey=HBWBJCSXUJIDGN-UHFFFAOYSA-N
• SMILES: Cc1cc(=O)n(-c2ccc(C)c(C)c2)[nH]1