(4aS,4bS,10aR,10bS,11S,12aS)-1,11-Dihydroxy-1-(hydroxymethyl)-10a,12a-dimethyl-4,4a,4b,5,6,10a,10b,11,12,12a-decahydrochrysene-2,8(1H,3H)-dione

Ref. TR-D489803

Información del producto

• Nombre: (4aS,4bS,10aR,10bS,11S,12aS)-1,11-Dihydroxy-1-(hydroxymethyl)-10a,12a-dimethyl-4,4a,4b,5,6,10a,10b,11,12,12a-decahydrochrysene-2,8(1H,3H)-dione

Descripción

Applications (4aS,4bS,10aR,10bS,11S,12aS)-1,11-Dihydroxy-1-(hydroxymethyl)-10a,12a-dimethyl-4,4a,4b,5,6,10a,10b,11,12,12a-decahydrochrysene-2,8(1H,3H)-dione is an intermediate in the synthesis of (11β)-11,17a-Dihydroxy-17a-[(phosphonooxy)methyl]-D-homoandrosta-1,4-diene-3,17-dione Ammonium Salt (D455580), which is a derivative of Prednisolone (P703740), a glucocorticosteroid that is used to treat patients with chronic obstructive pulmonary disease (COPD).
References Burge, P., et al.: Thorax, 58, 654 (2003); Mendenhall, C., et al.: New Engl. J. Med., 311, 1464 (1984)

• Marca: TRC

Propiedades químicas

• Peso molecular: 360.444
• Fórmula: C₂₁H₂₈O₅
• Color/Forma: White Foam
• InChI: InChI=1S/C21H28O5/c1-19-8-7-13(23)9-12(19)3-4-14-15-5-6-17(25)21(26,11-22)20(15,2)10-16(24)18(14)19/h7-9,14-16,18,22,24,26H,3-6,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21?/m0/s1
• Clave InChI: InChIKey=CMVZLQNFQDGAJK-ZQEPWLJWSA-N
• SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CCC(=O)C2(O)CO