2-{4-[N-(5,6-Diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butyl ester

CAS: 475084-96-9

Ref. TR-D525860

Información del producto

• Nombre: 2-{4-[N-(5,6-Diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butyl ester
• Sinónimos: Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-, 1,1-dimethylethyl ester (ACI), 1,1-Dimethylethyl 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]acetate (ACI), Acetic acid, [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-, 1,1-dimethylethyl ester (9CI)

Descripción

Applications 2-{4-[N-(5,6-Diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butyl ester is an impurity of Selexipag (S253150), an orally available, highly selective, long-acting prostacyclin (IP) receptor agonist prodrug. It is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.
References Kuwano, K., et al.: J. Pharm. Exp. Ther., 322, 1181 (2007);

• Marca: TRC

Propiedades químicas

• Peso molecular: 475.622
• Fórmula: C₂₉H₃₇N₃O₃
• Color/Forma: Neat
• InChI: InChI=1S/C29H37N3O3/c1-22(2)32(18-12-13-19-34-21-26(33)35-29(3,4)5)25-20-30-27(23-14-8-6-9-15-23)28(31-25)24-16-10-7-11-17-24/h6-11,14-17,20,22H,12-13,18-19,21H2,1-5H3
• Clave InChI: InChIKey=TUQMNTRUQSTQNJ-UHFFFAOYSA-N
• SMILES: CC(C)N(CCCCOCC(=O)OC(C)(C)C)c1cnc(-c2ccccc2)c(-c2ccccc2)n1