Entacapone

CAS: 130929-57-6

Ref. TR-E558500

Información del producto

• Nombre: Entacapone
• Sinónimos: (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide, (E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide, (E)-Entacapone, Comtan, OR 611, (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide, (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide, 2-Cyano-3-(5-Dihydroxyamino-3,4-Dioxo-1-Cyclohexa-1,5-Dienyl)-N,N-Diethyl-Prop-2-Enamide, 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-, 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (E)-, Comtess, Entacom, Or 611, Parkicapone

Descripción

Applications (E)-Isomer of Entacapone polymorphic form A. Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992); Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992); Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993);

• Marca: TRC

Propiedades químicas

• Peso molecular: 305.29
• Fórmula: C₁₄H₁₅N₃O₅
• Color/Forma: Off White
• InChI: InChI=1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+
• SMILES: CCN(CC)C(=O)/C(C#N)=C/c1cc(O)c(O)c([N+](=O)[O-])c1