N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine

CAS: 183321-74-6

Ref. TR-E625008

Información del producto

• Nombre: N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
• Sinónimos: Erlotinib, 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline, NSC 718781, OSI 744, R 1415, 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, 4-[(3-Ethynylphenyl)Amino]-6,7-Bis(2-Methoxyethoxy)Quinazoline, Erlotinib & its intermediates (Developing), Erlotinib Base, Erlotinin, N-(3-Ethynylphenyl)[6,7-Bis(2-Methoxyethoxy)Quinazolin-4-Yl]Amine, Osi 744
• CAS: 183321-74-6

Descripción

Applications Erlotinib is a EGFR-targeted drug in the treatment of non-small cell lung cancer. EGFR small tyrosine kinase inhibitor that shows most substantial effect on tumor growth inhibition and animal survival.
References Zhu, B., et al.: Xiandai Zhenduan Yu Zhiliao, 25, 4679 (2014); Yao, T., et al.: Ther. Targets Neurol. Dis., 2, 585 (2015)

• Marca: TRC

Propiedades químicas

• Peso molecular: 393.44
• Fórmula: C₂₂H₂₃N₃O₄
• Color/Forma: White to Off-White Solid
• InChI: InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
• SMILES: C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1