6-Ethylchenodeoxycholic Acid

CAS: 459789-99-2

Ref. TR-E899810

Información del producto

• Nombre: 6-Ethylchenodeoxycholic Acid
• Sinónimos: Cholan-24-oic acid, 6-ethyl-3,7-dihydroxy-, (3a,5ß,6a,7a)-, (3a,5ß,6a,7a)-6-Ethyl-3,7-dihydroxycholan-24-oic acid, 3a,7ß-Dihydroxy-6a-ethyl-5ß-cholan-24-oic acid, 6-ECDCA, 6a-Ethylchenodeoxycholic acid, INT 747, Obeticholic acid, Ocaliva, (3α,5β,6α,7α)-6-Ethyl-3,7-dihydroxycholan-24-oic acid, 3α,7β-Dihydroxy-6α-ethyl-5β-cholan-24-oic acid, 6-Ecdca, 6-Ethylchenodeoxycholic acid, 6α-Ethylchenodeoxycholic acid, Cholan-24-oic acid, 6-ethyl-3,7-dihydroxy-, (3α,5β,6α,7α)-, Int 747, Obeticholic Acid

Descripción

Applications 6-Ethylchenodeoxycholic Acid is a derivative of the bile acid Chenodeoxycholic Acid (C291900). 6-Ethylchenodeoxycholic Acid is a potent activator of the farnesoid X nuclear receptor which reduces liver fat and fibrosis in animal models of fatty liver disease.
References Neuschwander-Tetri, B.A., et al.: Lancet., 385, 956 (2015);

• Marca: TRC

Propiedades químicas

• Peso molecular: 420.63
• Fórmula: C₂₆H₄₄O₄
• Color/Forma: White To Off-White
• InChI: InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1
• Clave InChI: InChIKey=ZXERDUOLZKYMJM-ZWECCWDJSA-N
• SMILES: CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O