4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzenamine

CAS: 630125-91-6

Ref. TR-E924295

Información del producto

• Nombre: 4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzenamine
• Sinónimos: 3-Trifluoromethyl-4-(4-ethylpiperazin-1-ylmethyl)phenylamine, 4-((4-Ethylpiperazine-1-yl)methyl)-3-(trifluoromethyl)aniline, 4-(4-Ethylpiperazin-1-ylmethyl)-3-trifluoromethylaniline, [4-(4-Ethylpiperazin-1-ylmethyl)-3-trifluoromethylphenyl]amine
• Marca: TRC
• Descripción: Applications 4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzenamine is one of the key reactants with N-[1-(4-Aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide used in the synthesis of a pyrrolo[3,2-c]pyridine derivative [N-[1-[4-[[[[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide (I)], an anticancer diarylurea derivative with multiple-kinase inhibitory effect; Also, it is an intermediate used in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.References El-Gamal, M. I., et al.: Bull. Korean Chem. Soc., 33, 1571-1576 (2012); Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010)

Propiedades químicas

• Peso molecular: 287.324
• Fórmula: C₁₄H₂₀F₃N₃
• Color/Forma: Neat
• InChI: InChI=1S/C14H20F3N3/c1-2-19-5-7-20(8-6-19)10-11-3-4-12(18)9-13(11)14(15,16)17/h3-4,9H,2,5-8,10,18H2,1H3
• Clave InChI: InChIKey=ZYWCDXFRHUHFNV-UHFFFAOYSA-N
• SMILES: CCN1CCN(Cc2ccc(N)cc2C(F)(F)F)CC1