N-Formyl 10-Oxo 7-Epi-docetaxel

Ref. TR-F700768

Información del producto

• Nombre: N-Formyl 10-Oxo 7-Epi-docetaxel
• Sinónimos: (2aR,4R,4aS,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-formamido-2-hydroxy-3-phenylpropanoyl)oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5,6-dioxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Benzoate

Descripción

Applications N-Formyl 10-Oxo 7-Epi-docetaxel is an epimer of N-Formyl 10-Oxo Docetaxel (F700765), which is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel(P132500), an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antine oplastic.
References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)

• Marca: TRC

Propiedades químicas

• Peso molecular: 733.76
• Fórmula: C₃₉H₄₃NO₁₃
• Color/Forma: Off-White Solid
• InChI: InChI=1S/C39H43NO13/c1-20-24(51-35(48)30(45)28(40-19-41)22-12-8-6-9-13-22)17-39(49)33(52-34(47)23-14-10-7-11-15-23)31-37(5,32(46)29(44)27(20)36(39,3)4)25(43)16-26-38(31,18-50-26)53-21(2)42/h6-15,19,24-26,28,30-31,33,43,45,49H,16-18H2,1-5H3,(H,40,41)/t24-,25+,26+,28-,30+,31-,33-,37+,38-,39+/m0/s1
• Clave InChI: InChIKey=ZTVQUNHGDZUXSD-BXXIJZFJSA-N
• SMILES: CC(=O)O[C@@]12CO[C@@H]1C[C@@H](O)[C@@]1(C)C(=O)C(=O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC=O)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C