(E)-N-(4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-N-methylethenesulfonamide

Ref. TR-F898545

Información del producto

• Nombre: (E)-N-(4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-N-methylethenesulfonamide

Descripción

Applications (E)-N-(4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-N-methylethenesulfonamide is an intermediate for the synthesis of S-Demethyl (E)-S-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-ethenyl Rosuvastatin (D231085), which is a dimerized impurity of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor.

• Marca: TRC

Propiedades químicas

• Peso molecular: 686.792
• Fórmula: C₃₂H₃₆F₂N₆O₅S₂
• Color/Forma: Off-White Solid
• InChI: InChI=1S/C32H36F2N6O5S2/c1-19(2)27-25(29(21-8-12-23(33)13-9-21)37-31(35-27)39(5)46(7,42)43)16-17-47(44,45)40(6)32-36-28(20(3)4)26(18-41)30(38-32)22-10-14-24(34)15-11-22/h8-17,19-20,41H,18H2,1-7H3/b17-16+
• Clave InChI: InChIKey=GRSYQXZIAJJRKL-WUKNDPDISA-N
• SMILES: CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1/C=C/S(=O)(=O)N(C)c1nc(-c2ccc(F)cc2)c(CO)c(C(C)C)n1