Genistein

CAS: 446-72-0

Ref. TR-G350000

Información del producto

• Nombre: Genistein
• Sinónimos: 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-, Genistein (6CI), Isoflavone, 4',5,7-trihydroxy- (8CI), 4',5,7-Trihydroxyisoflavone, 5,7,4'-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one, Baichanin A, Bonistein, C.I. 75610, Climagen F, FW 635I-2, GeniVida, Genisteol, Genisterin, Genistin aglycone, NPI 031L, NSC 36586, Prunetol, SIPI 807-1, Sophoricol, 4′,5,7-Trihydroxyisoflavone, 5,7-Dihidroxi-3-(4-Hidroxifenil)-4-Benzopirona, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone, Bio 300, Csu 1999, Fw 635I-2, Isoflavone, 4',5,7-trihydroxy-, Isoflavone, 4′,5,7-trihydroxy-, Npi 031L, Nsc 36586, Sipi 807-1, 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-

Descripción

Stability Light Sensitive
Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995), Merck Index 12th ed. 4395, Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)

• Marca: TRC

Propiedades químicas

• Peso molecular: 270.24
• Fórmula: C₁₅H₁₀O₅
• Color/Forma: Light Yellow
• InChI: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
• Clave InChI: InChIKey=TZBJGXHYKVUXJN-UHFFFAOYSA-N
• SMILES: O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12