TR-G765005 - gly-gly-leu | 14857-82-0

The dipeptide Leu-Gly inhibits the ubiquitin-mediated proteolysis.

A bitter-tasting dipeptide, which activates the human bitter receptors hTAS2Rs. GL is a good substrate for dipeptide hydrolase activities in rat intestinal mucosa and human kidney.

Substrate for the characterization of tripeptide aminopeptidase from monkey brain. A specific kinetic assay for this enzyme in serum has been described.

Chromogenic substrate for the assay of collagenase and thimet oligopeptidase (Pz-peptidase, metalloendopeptidase 24.15, collagenase-like peptidase). Enzymatic cleavage yields Pz-Pro-Leu-OH (or Pz-Pro-OH). The cleavage can be monitored by analytical HPLC, detection at 320 nm.

Leu-Gly-βNA was used for characterizing dipeptidyl aminopeptidase (DAP) activity in pupae and adult extracts of Apis mellifera.

The chromogenic substrate Z-GGL-pNA is used alone or in combination with other substrates as Suc-LLVY-AMC for measuring the chymotrypsin-like activity of the proteasome. Z-GGL-pNA is also cleaved by proteinase yscE (kexin), subtilisins, and neutral endopeptidase 24.5.

FAGLA is a good substrate for thermolysin, the Bacillus subtilis neutral protease, and the fibrinolytic neutral metalloendopeptidase EM 19000 from Streptococcus faecalis.

Suc-GPLGP-AMC, a highly sensitive, fluorogenic substrate for thimet oligopeptidase (collagenase-like peptidase, Pz-peptidase, metalloendopeptidase 24.15) as well as for post-proline cleaving enzyme (prolyl endopeptidase).

Formally derived from the C-terminal dipeptide of oxytocin., cyclo(Leu-Gly) is active in memory processes. The diketopiperazine blocks the narcotic-induced dopamine receptor supersensitivity.

<p>Bachem ID: 4005544.</p>

Boc-LGR-AMC, a specific fluorogenic substrate for complement component C3/C5 convertases, coagulation factor Xa, and soybean trypsin-like enzyme. It is also hydrolyzed by macropain, a high molecular weight thiol proteinase from human erythrocytes. Stock solutions of Boc-LGR-AMC are best prepared in DMSO.

Substrate for a versatile, convenient, continuously recording spectrophotometric assay of collagenase.

Bz-RGFFL-MNA, substrate for cathepsin D.

Z-MIF I (free acid).

Affinity ligand for the purification of human collagenases. Inhibitor of MMP-8, Ki 19 μM (Grams et al., 1995).

The thiopeptolide Ac-Pro-Leu-Gly-psi[COS]Leu-Leu-Gly-OEt is used as substrate in a rapid, sensitive, continuous spectrophotometric assay for vertebrate collagenase, gelatinase A, and gelatinase B. Besides the mercaptan to be determined, cleavage yields Ac-PLG.

Z-GGL-AMC, a fluorogenic substrate for the chymotrypsin-like activity of the 20S proteasome. Sensitive fluorogenic substrate for subtilisins BPN’ and Carlsberg. Also cleaved by ClpP protease from M. tuberculosis.

A fluorogenic substrate for neutral metalloendopeptidases, e.g. Pseudomonas aeruginosa elastase, enkephalinase (NEP 24.11), and thermolysin. Abz-AGLA-Nba is also cleaved by atrolysin B and C.

Fmoc-Leu-Gly can self-assemble forming ultrathin hydrogel membranes.

<p>Bachem ID: 4015627.</p>