Guvacine Hydrochloride

CAS: 6027-91-4

Ref. TR-G876400

Información del producto

• Nombre: Guvacine Hydrochloride
• Sinónimos: 1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydrochloride, 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride (1:1), 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride, Nicotinic acid, 1,2,5,6-tetrahydro-, hydrochloride, 1,2,5,6-Tetrahydropyridine-3-carboxylic acid hydrochloride, Guvacine, hydrochloride

Descripción

Applications Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders.
References (1) Lesnefsky, E., et al.: J. Biol. Chem., 279, 47961 (2004) (2) Nadtochiy, S., et al.: Biochem. J., 395, 611 (2006) (3) Corns, L.F., et al.: Neurosci Lett. 553, 57 (2013). (4) Borden, L. A., et al.: Eur J Pharmacol. 269, 219 (1994)

• Marca: TRC

Propiedades químicas

• Peso molecular: 163.60
• Fórmula: C₆H₉NO₂·ClH
• Color/Forma: Neat
• InChI: InChI=1S/C6H9NO2.ClH/c8-6(9)5-2-1-3-7-4-5;/h2,7H,1,3-4H2,(H,8,9);1H
• Clave InChI: InChIKey=FGNUNVVTHHKDAM-UHFFFAOYSA-N
• SMILES: Cl.O=C(O)C1=CCCNC1