11a-Hydroxy Canrenone

CAS: 192569-17-8

Ref. TR-H883500

Información del producto

• Nombre: 11a-Hydroxy Canrenone
• Sinónimos: Pregna-4,6-diene-21-carboxylic acid, 11,17-dihydroxy-3-oxo-, ?-lactone, (11a,17a)-, 11a-Hydroxycanrenone, (11A,17A)-11,17-Dihydroxy-3-Oxo-Pregna-4,6-Diene-21-Carboxylic Acid, (11α, 17α)-11,17-Dihydroxy-3-oxo-pregna-4,6-diene-21-carboxylic acid-τ-lactone, 11-Alpha-Hydroxy-Carnrenone, 11-Hydroxy-Canrenone, 11-a-Hydroxy canrenone, 11Alpha-HydroxyCanrenone, 11α-Hydroxycanrenone, 3-(3-Oxo-11A,17-Dihydroxy-4,6-Diene-Pregna-17A-Yl)Propanoicacidlactone, 3-(3-Oxo-11A,17Ss-Dihydroxy-4,6-Diene-Pregna-17A-Yl)Propanoic Acid Lactone, Pregna-4,6-diene-21-carboxylic acid, 11,17-dihydroxy-3-oxo-, γ-lactone, (11α,17α)-

Descripción

Applications 11α-Hydroxy Canrenone is the key intermediate in the synthesis of Eplerenone, a cardiovascular drug. Canrenone was biotransformed into 11α-Hydroxycanrenone by Aspergillus ochraceus SIT34205.
References Luetscher, J., et al.: J. Clin. Invest., 29, 1576 (1950), Gaunt, R., et al.: J. Clin. Endocrinol. Metab., 15, 621 (1955), McMahon, E., et al.: Curr. Opin. Pharm., 1, 190 (2001), McMahon, E., et al.: Curr. Pharm. Des., 9, 1065 (2003),

• Marca: TRC

Propiedades químicas

• Peso molecular: 356.46
• Fórmula: C₂₂H₂₈O₄
• Color/Forma: Neat
• InChI: InChI=1S/C22H28O4/c1-20-8-5-14(23)11-13(20)3-4-15-16-6-9-22(10-7-18(25)26-22)21(16,2)12-17(24)19(15)20/h3-4,11,15-17,19,24H,5-10,12H2,1-2H3/t15-,16-,17+,19+,20-,21-,22+/m0/s1
• Clave InChI: InChIKey=RJTDWMKVQUPGSY-GOAYFHFKSA-N
• SMILES: C[C@]12C[C@@H](O)C3C(C=CC4=CC(=O)CC[C@@]43C)C1CC[C@@]21CCC(=O)O1