(E)-4-Hydroxy-N-desmethyl Tamoxifen

CAS: 114828-90-9

Ref. TR-H938495

Información del producto

• Nombre: (E)-4-Hydroxy-N-desmethyl Tamoxifen
• Sinónimos: 4-[(1E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol, E-Endoxifen

Descripción

Applications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.
References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003),

• Marca: TRC

Propiedades químicas

• Peso molecular: 373.49
• Fórmula: C₂₅H₂₇NO₂
• Color/Forma: Neat
• InChI: InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/b25-24+
• Clave InChI: InChIKey=MHJBZVSGOZTKRH-OCOZRVBESA-N
• SMILES: CC/C(=C(/c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1