5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers)

CAS: 504413-73-4

Ref. TR-H954455

Información del producto

• Nombre: 5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers)
• Sinónimos: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9,12-trihydroxy-, (4S)-, (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9,12-trihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-Hydroxy-9-[(dimethylamino)methyl]-5-hydroxy-(20S,5RS)-camptothecin
• CAS: 504413-73-4

Descripción

Stability Hygroscopic
Applications Dihydrochloride Salt of 5-Hydroxy Topotecan, is the metabolite of Topotecan (T542500), which is a DNA topoisomerase I inhibitor, semi synthetic analog of Camptothecin, and an antineoplastic.
References Beijnen, J.H., et al.: J. Pharm. Biomed. Anal., 8, 789 (1990), BeiKingsburg, W.D., et al.: J. Med. Chem., 34, 98 (1991), Rowinsky, E.K., et al.: J. Clin. Oncol., 10, 647 (1992),

• Marca: TRC

Propiedades químicas

• Peso molecular: 437.45
• Fórmula: C₂₃H₂₅Cl₂N₃O₆
• Color/Forma: Neat
• InChI: InChI=1S/C23H23N3O6/c1-4-23(31)15-8-17-19-12(20(28)26(17)21(29)14(15)10-32-22(23)30)7-11-13(9-25(2)3)18(27)6-5-16(11)24-19/h5-8,20,27-28,31H,4,9-10H2,1-3H3/t20?,23-/m0/s1
• Clave InChI: InChIKey=IKBVYIZOTSVDNQ-AKRCKQFNSA-N
• SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)C(O)c2cc3c(CN(C)C)c(O)ccc3nc2-1