IDRA-21

CAS: 22503-72-6

Ref. TR-I232500

Información del producto

• Nombre: IDRA-21
• Sinónimos: 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-Dioxide, 2H-1,2,4-Benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide, 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide, 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide, Idra 21

Descripción

Applications IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer's disease.
References (1) Malkova, L, et al.: Neuropharmacology. 60, 1262 (2011)(2) Dingledine, R., et al.: Pharmacol. Rev., 51, 7 (1999)(3) Sun, Y., et al.: Nature, 417, 245 (2002) (4) Thomsen, R., et al.: J. Med. Chem., 49, 3315 (2006)

• Marca: TRC

Propiedades químicas

• Peso molecular: 232.69
• Fórmula: C₈H₉ClN₂O₂S
• Color/Forma: Neat
• InChI: InChI=1S/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3
• Clave InChI: InChIKey=VZRNTCHTJRLTMU-UHFFFAOYSA-N
• SMILES: CC1Nc2ccc(Cl)cc2S(=O)(=O)N1