Indirubin-3'-monoxime

CAS: 160807-49-8

Ref. TR-I527500

Información del producto

• Nombre: Indirubin-3'-monoxime
• Sinónimos: Indirubin-3’-oxime, 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one, ；3-[1,3-Dihydro-3-(Hydroxyimino)-2H-Indol-2-Ylidene]-1,3-Dihydro-2H-Indol-2-One, Indirubin-3'-Oxime, Indirubine-3'-oxime；, 3-(hydroxyamino)-1H,2'H-2,3'-biindol-2'-one

Descripción

Stability Light Sensitive
Applications A potent inhibitor of GSK-3ß (IC50=22nM). Also inhibits CDK1 (IC50=180nM) and CDK (IC50=100nM). It reversibly arrests asynchronous HBL-100 cells at G2. It induces apoptosis in the mammary carcinoma cell line MCF-7 (10üM).
References Leclerc, S., et al.: J. Biol. Chem., 276, 251 (2001), Damiens, E., et al.: Oncogene, 20, 3786 (2001), Marko, D., et al.: Br. J. Cancer, 84, 283 (2001)

• Marca: TRC

Propiedades químicas

• Peso molecular: 277.28
• Fórmula: C₁₆H₁₁N₃O₂
• Color/Forma: Dark Red Solid
• InChI: InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17,21H,(H,18,20)/b15-13-,19-14+
• Clave InChI: InChIKey=HBDSHCUSXQATPO-BGBJRWHRSA-N
• SMILES: O=C1Nc2ccccc2/C1=C1/Nc2ccccc2/C1=N\O