(R)-Irofulven

CAS: 158440-71-2

Ref. TR-I769500

Información del producto

• Nombre: (R)-Irofulven
• Sinónimos: (6'R)-6'-Hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, (-)-(Hydroxymethyl)acylfulvene, (-)-Irofulven, HMAF, MGI 114, NSC 683863, (6'R)-6'-hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro[cyclopropane-1,5'-inden]-7'(6'H)-one, (6′R)-6′-Hydroxy-3′-(hydroxymethyl)-2′,4′,6′-trimethylspiro[cyclopropane-1,5′-[5H]inden]-7′(6′H)-one, 6-Hmaf, Hmaf, Hydroxymethylacylfulvene, Irofulven, Mgi-114, Nsc-683863, Spiro[cyclopropane-1,5′-[5H]inden]-7′(6′H)-one, 6′-hydroxy-3′-(hydroxymethyl)-2′,4′,6′-trimethyl-, (6′R)-, Spiro[cyclopropane-1,5′-[5H]inden]-7′(6′H)-one, 6′-hydroxy-3′-(hydroxymethyl)-2′,4′,6′-trimethyl-, (R)-

Descripción

Applications Semi-synrhetic antitumor agent derived from Illudin S. Inhibits DNA synthesis and induces apoptosis in tumor cells. Antineoplastic.
References Woynarowski, J.M., et al.: Biochem. Pharmacol., 54, 1181 (1997), Alexandre, J., et al.: Clin. Cancer Res., 10, 3377 (2004), Senzer, N., et al.: Am. J. Clin. Oncol., 28, 36 (2005),

• Marca: TRC

Propiedades químicas

• Peso molecular: 246.31
• Fórmula: C₁₅H₁₈O₃
• Color/Forma: Neat
• InChI: InChI=1S/C15H18O3/c1-8-6-10-12(11(8)7-16)9(2)15(4-5-15)14(3,18)13(10)17/h6,16,18H,4-5,7H2,1-3H3/t14-/m0/s1
• Clave InChI: InChIKey=NICJCIQSJJKZAH-AWEZNQCLSA-N
• SMILES: CC1=C(CO)C2=C(C)C3(CC3)[C@@](C)(O)C(=O)C2=C1