Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt

CAS: 1520010-86-9

Ref. TR-I824640

Información del producto

• Nombre: Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt
• Sinónimos: N-(Hydroxyphenoxyphosphinyl)-L-alanine 1-Methylethyl Ester Sodium Salt, (2S)-Isopropyl 2-((Hydroxy(phenoxy)phosphoryl)amino)propanoate Sodium Salt
• CAS: 1520010-86-9

Descripción

Applications Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt is an impurity of Sofosbuvir (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);

• Marca: TRC

Propiedades químicas

• Peso molecular: 309.23
• Fórmula: C₁₂H₁₇NNaO₅P
• Color/Forma: Neat
• InChI: InChI=1S/C12H18NO5P.Na/c1-9(2)17-12(14)10(3)13-19(15,16)18-11-7-5-4-6-8-11;/h4-10H,1-3H3,(H2,13,15,16);/q;+1/p-1/t10-;/m0./s1