(-)-α-Kainic Acid Monohydrate

CAS: 58002-62-3

Ref. TR-K445000

Información del producto

• Nombre: (-)-α-Kainic Acid Monohydrate
• Sinónimos: (2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid;hydrate, (-)-Kainic acid Monohydrat, (3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-yl-L-proline hydrate (1:1), Kainic Acid 2-Carboxy-3-Carboxymethyl-4-Isopropenylpyrrolidine

Descripción

Applications (-)-α-Kainic Acid Monohydrate is the monohydrated form of (-)-α-Kainic Acid (K135010); a naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.
References Wacker, D.A., et al.: Synlett, 503 (1997); Dunleavy, M., et al.: J. Molec. Neurosci., 49, 202 (2013); Zhang, J., et al.: Neuron., 76, 1133 (2012); Yamada, J., et al.: Neurosci., 226, 119 (2012); Wang,Q., et al.: Mol. Neurobiol., 31, 3 (2005)

• Marca: TRC

Propiedades químicas

• Peso molecular: 231.246
• Fórmula: C₁₀H₁₅NO₄·H₂O
• Color/Forma: Neat
• InChI: InChI=1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1
• Clave InChI: InChIKey=ZFKWIQIRGQWRDP-XLVPUTSBSA-N
• SMILES: CO[C@@H]1[C@@H](O[C@@H]2OC(C)[C@H](O[C@H]3CC(C)(O)[C@@H](O)C(C)O3)C(N(C)C)C2O)[C@H]2CC(O[Si](C)(C)C(C)(C)C)O[C@@H]1CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O[C@H]1CC[C@@H](N(C)C)C(C)O1)[C@H](C)C2