LEE 011

CAS: 1211441-98-3

Ref. TR-L178830

Información del producto

• Nombre: LEE 011
• Sinónimos: 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-, 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Kisqali, LEE 011A, Ribociclib, 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-, Lee 011A
• CAS: 1211441-98-3

Descripción

Applications LEE 011 can be used in biological study of kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer.
References Jansen, V. M., et al.: Cancer Research, 77, 2488 (2017)

• Marca: TRC

Propiedades químicas

• Peso molecular: 434.54
• Fórmula: C₂₃H₃₀N₈O
• Color/Forma: Neat
• InChI: InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
• Clave InChI: InChIKey=RHXHGRAEPCAFML-UHFFFAOYSA-N
• SMILES: CN(C)C(=O)c1cc2c[nH]c(=Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1