Methyl 2-((((Benzyloxy)carbonyl)amino)methyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate

Ref. TR-M292785

Información del producto

• Nombre: Methyl 2-((((Benzyloxy)carbonyl)amino)methyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate

Descripción

Applications Methyl 2-((((Benzyloxy)carbonyl)amino)methyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate is an intermediate used in the synthesis of N-((5-Hydroxy-6-oxo-4-((2,4,6-trifluorobenzyl)carbamoyl)-1,6-dihydropyrimidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide (H950690), which is a derivative of Raltegravir (R100305), a potent integrase (IN) inhibitor for WT and S217Q PFV IN.
References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)

• Marca: TRC

Propiedades químicas

• Peso molecular: 333.296
• Fórmula: C₁₅H₁₅N₃O₆
• Color/Forma: Neat
• InChI: InChI=1S/C15H15N3O6/c1-23-14(21)11-12(19)13(20)18-10(17-11)7-16-15(22)24-8-9-5-3-2-4-6-9/h2-6,19H,7-8H2,1H3,(H,16,22)(H,17,18,20)
• Clave InChI: InChIKey=YTMYARBSRVCTMN-UHFFFAOYSA-N
• SMILES: COC(=O)c1nc(CNC(=O)OCc2ccccc2)[nH]c(=O)c1O