PAC-1

CAS: 315183-21-2

Ref. TR-P132000

Información del producto

• Nombre: PAC-1
• Sinónimos: 4-(Phenylmethyl)-1-piperazineacetic Acid 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl] methylene]hydrazide, Procaspase Activating Compound 1, 1-Piperazineacetic acid, 4-(phenylmethyl)-, 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide, 1-Piperazineacetic acid, 4-(phenylmethyl)-, [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide, Pac-1, Pac1, Procaspase activating compound 1
• CAS: 315183-21-2

Descripción

Applications PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Slee, E., et al.: J. Biol. Chem., 276, 7320 (2001), Pop, C., et al.: Biochemistry, 42, 12311 (2003), Li, L., et al.: Science, 305, 1471 (2004), Green, D., et al.: J. Clin. Invest., 115, 2610 (2005), Satoh, T., et al.: Clin. Cancer Res., 15, 3872 (2009),

• Marca: TRC

Propiedades químicas

• Peso molecular: 392.49
• Fórmula: C₂₃H₂₈N₄O₂
• Color/Forma: White to Off-White Solid
• InChI: InChI=1S/H3N/h1H3
• Clave InChI: InChIKey=QGZKDVFQNNGYKY-UHFFFAOYSA-N
• SMILES: CC(=O)OC1C2OC(C)(C)OC[C@@H]2O[C@@H]1COP(=O)(OCCC#N)OCCC#N