Palonosetron 8-Hydroxy 1-Carboxamide

CAS: 1227162-74-4

Ref. TR-P165840

Información del producto

• Nombre: Palonosetron 8-Hydroxy 1-Carboxamide
• Sinónimos: N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-8-hydroxy-5,6,7,8-tetrahydronaphthalene-1-carboxamide

Descripción

Applications Palonosetron 8-Hydroxy 1-Carboxamide is an impurity of Palonosetron(P165830). Palonosetron is a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References Tricco, A. C., et al.: BMC Medicine, 14, 216 (206); Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

• Marca: TRC

Propiedades químicas

• Peso molecular: 300.395
• Fórmula: C₁₈H₂₄N₂O₂
• Color/Forma: Neat
• InChI: InChI=1S/C18H24N2O2/c21-16-6-2-4-13-3-1-5-14(17(13)16)18(22)19-15-11-20-9-7-12(15)8-10-20/h1,3,5,12,15-16,21H,2,4,6-11H2,(H,19,22)/t15-,16?/m1/s1
• Clave InChI: InChIKey=JFJFGAXBBDZTEE-AAFJCEBUSA-N
• SMILES: O=C(N[C@@H]1CN2CCC1CC2)c1cccc2c1C(O)CCC2