RTA 408

CAS: 1474034-05-3

Ref. TR-R700990

Información del producto

• Nombre: RTA 408
• Sinónimos: N-(2-Cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoropropanamide, Omaveloxolone
• CAS: 1474034-05-3

Descripción

Applications Synthetic triterpenoids, such as RTA 408, are antioxidant inflammation modulator (AIM) that can inhibit tumor cell growth and metastasis via oncogenic signaling pathways. RTA 408 is an anticancer, anti-inflammatory, and antioxidant agent that protects human retinal pigment epithelial cells against H2O2-induced cell injury by activating NF-E2-related factor 2.
References Liu, X., et al.: Redox Biol. 8, 98 (2016); Probst, B. L., et al.: PLoS One. 10, e0122942 (2015)

• Marca: TRC

Propiedades químicas

• Peso molecular: 554.711
• Fórmula: C₃₃H₄₄F₂N₂O₃
• Color/Forma: White to Off-White Solid
• InChI: InChI=1S/C33H44F2N2O3/c1-27(2)11-13-33(37-26(40)32(8,34)35)14-12-31(7)24(20(33)17-27)21(38)15-23-29(5)16-19(18-36)25(39)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3,(H,37,40)/t20-,22-,24-,29-,30+,31+,33-/m0/s1
• SMILES: CC1(C)CC[C@]2(NC(=O)C(C)(F)F)CC[C@]3(C)[C@H](C(=O)C=C4[C@@]3(C)CC[C@H]3C(C)(C)C(=O)C(C#N)=C[C@]43C)[C@@H]2C1